Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Over the last two decades, an additional and important role for B cells has been established in immune regulation. Preclinical studies demonstrate that regulatory B cells (Breg) can prolong allograft survival in animal models and induce regulatory T cells. Operationally tolerant human kidney transplant recipients demonstrate B-cell-associated gene signatures of immune tolerance, and novel therapeutic agents can induce Bregs in phase I clinical trials in transplantation. Our rapidly expanding appreciation of this novel B-cell subtype has made the road to clinical application a reality. Here, we outline several translational pathways by which Bregs could soon be introduced to the transplant clinic.

Original publication

DOI

10.1111/tri.13706

Type

Journal article

Journal

Transpl Int

Publication Date

11/2020

Volume

33

Pages

1353 - 1368

Keywords

B cells, T cells, immunosuppression, immunosuppression experimental, macrophages, novel immunosuppressants, tolerance induction, tolerance strategies and mechanisms, Animals, B-Lymphocytes, Regulatory, Humans, Immune Tolerance, T-Lymphocytes, Regulatory, Transplantation Tolerance, Transplantation, Homologous