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<p>Supplementary Material, including Supplementary Methods describing the Random Effects Model. Supplementary Results showing example quantitative T1/T2 maps from the rat tumour model (Supplementary Figure S1), the standard curve for making quantitative protein concentration measurements using Coomassie staining (Supplementary Figure S2), the result of a conventional MTRasym APT analysis approach in the rat tumour model (Supplementary Figure S3), and the histological validation that areas of high protein concentration correlate with areas of increased hypoxia, increased vessel area and higher cellularity in the rat tumour model (Supplementary Figure S4). Supplementary Table S1 shows the mean {plus minus} standard deviation of T1 and T2 relaxation times measured in different tissue ROIs from both the rat tumour and mouse tumour models.</p>

Original publication

DOI

10.1158/0008-5472.22421936

Type

Other

Publication Date

31/03/2023