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We examined the safety, immunogenicity and efficacy of a prime-boost vaccination regime involving two poxvirus malaria subunit vaccines, FP9-PP and MVA-PP, expressing the same polyprotein consisting of six pre-erythrocytic antigens from Plasmodium falciparum. Following safety assessment of single doses, 15 volunteers received a heterologous prime-boost vaccination regime and underwent malaria sporozoite challenge. The vaccines were safe but interferon-γ ELISPOT responses were low compared to other poxvirus vectors, despite targeting multiple antigens. There was no vaccine efficacy as measured by delay in time to parasitaemia. A number of possible explanations are discussed, including the very large insert size of the polyprotein transgene.

Original publication

DOI

10.1016/j.vaccine.2011.03.083

Type

Journal article

Journal

Vaccine

Publication Date

06/10/2011

Volume

29

Pages

7514 - 7522

Keywords

Adolescent, Adult, Antibodies, Protozoan, Antigens, Protozoan, Humans, Immunization, Secondary, Interferon-gamma, Malaria Vaccines, Malaria, Falciparum, Middle Aged, Plasmodium falciparum, Polyproteins, Protozoan Proteins, Treatment Outcome, Vaccination, Vaccines, Subunit, Young Adult