Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1-Å resolution in the postfusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat, and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion.

Original publication

DOI

10.1128/JVI.02298-13

Type

Journal article

Journal

J Virol

Publication Date

12/2013

Volume

87

Pages

13070 - 13075

Keywords

Amino Acid Sequence, Arenaviruses, New World, Cell Line, Crystallography, X-Ray, Glycosylation, Hemorrhagic Fever, American, Humans, Models, Molecular, Molecular Sequence Data, Protein Structure, Secondary, Sequence Alignment, Viral Fusion Proteins, Virus Internalization