A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
van Heel DA., Franke L., Hunt KA., Gwilliam R., Zhernakova A., Inouye M., Wapenaar MC., Barnardo MCNM., Bethel G., Holmes GKT., Feighery C., Jewell D., Kelleher D., Kumar P., Travis S., Walters JRF., Sanders DS., Howdle P., Swift J., Playford RJ., McLaren WM., Mearin ML., Mulder CJ., McManus R., McGinnis R., Cardon LR., Deloukas P., Wijmenga C.
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.