Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The immune system presents a significant challenge to the success of clinical transplantation. For the majority of patients, treatment with a combination of immunosuppressive drugs are essential to prevent rejection. Tissue injury caused by organ retrieval and implantation triggers an innate immune response, which in turn, activates the adaptive immune system capable of responding to both major and minor histocompatibility antigens mismatched between the organ donor and the recipient. Advances in immunosuppressive strategies using small molecules and biological agents have revolutionized the management and outcomes of solid organ transplantation.

Original publication

DOI

10.1016/B978-0-7020-6896-6.00081-8

Type

Chapter

Book title

Clinical Immunology: Principles and Practice

Publication Date

01/01/2019

Pages

1097 - 1114.e1