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Two-photon excitation with a mode-locked titanium: sapphire laser at 700 nm and confocal fluorescence microscopy have been used to detect single Coumarin-120 (C-120) molecules. The dye C-120 is quenched by the nucleobases, if coupled to nucleotides, resuiting in nucleobase-specific fluorescence lifetimes. This suggests applications in current projects for ultrasensitive DNA characterization.

Original publication

DOI

10.1080/07328319708002915

Type

Journal article

Journal

Nucleosides and Nucleotides

Publication Date

01/01/1997

Volume

16

Pages

551 - 556