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BACKGROUND: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. METHODS: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. RESULTS: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. CONCLUSIONS: nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.

Original publication

DOI

10.1111/j.1468-1293.2006.00341.x

Type

Journal article

Journal

HIV Med

Publication Date

03/2006

Volume

7

Pages

75 - 84

Keywords

Adolescent, Amino Acid Sequence, CD4 Lymphocyte Count, Child, Child, Preschool, Disease Progression, Female, Genes, MHC Class I, Genes, nef, HIV Infections, HIV Long-Term Survivors, HIV-1, Humans, Infant, Male, Molecular Sequence Data, Phylogeny, Polymorphism, Genetic, Sequence Alignment, Sequence Analysis, DNA, Viral Load