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A clone isolated from a tick salivary gland cDNA library encodes a homologue of the human Ki lupus autoantigen, a protein of unknown function that is related to the subunits of the PA28 proteasome activator. The Ki sequences appear to be well conserved between mammals and invertebrates, with 55% identity between the tick and human primary structures. This is the first report of a Ki homologue in invertebrates.

Type

Journal article

Journal

Biochim Biophys Acta

Publication Date

11/11/1996

Volume

1309

Pages

9 - 13

Keywords

Amino Acid Sequence, Animals, Autoantigens, Base Sequence, DNA, Complementary, Guinea Pigs, Humans, Molecular Sequence Data, Muscle Proteins, Nuclear Proteins, Proteasome Endopeptidase Complex, Proteins, Salivary Glands, Sequence Homology, Amino Acid, Ticks