Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The hypothesis that the intrapatient emergence of cytotoxic T-lymphocyte escape variants contributes to the evolution of human immunodeficiency virus type 1 at the population (interpatient) level was tested using the HLA-A*0201-restricted gag p17 epitope SLYNTVATL. Using a simple experimental design, we investigated the evolutionary processes operating within this epitope among patients while compensating for the confounding influence of intrapatient natural selection. Using this approach, we revealed a pattern of A*0201-driven escape within patients, followed by the sustained transmission of these escape variants among patients irrespective of their HLA type.

Original publication

DOI

10.1128/JVI.79.14.9363-9366.2005

Type

Journal article

Journal

J Virol

Publication Date

07/2005

Volume

79

Pages

9363 - 9366

Keywords

Acquired Immunodeficiency Syndrome, Amino Acid Sequence, Epitopes, T-Lymphocyte, HIV-1, HLA-A Antigens, Humans, Molecular Sequence Data, Selection, Genetic, T-Lymphocytes, Cytotoxic