Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The Peyer's patches (PP) and mesenteric lymph nodes (MLN) are structural components of the gut-associated lymphoid tissues and contribute to the induction of immune responses toward infection in the gastrointestinal tract. These secondary lymphoid organs provide structural organization for efficient cellular interactions and the initiation of primary adaptive immune responses against infection. Immunity against primary infection with the enteric apicomplexan parasite, Eimeria vermiformis, depends on the rapid induction of local Th1 responses. Lymphotoxin (LT)-deficient mice which have various defects in secondary lymphoid organs were infected with E. vermiformis. The relative susceptibility of LTalpha(-/-), LTbeta(-/-), LTalpha(+/-)beta(+/-) mice and bone marrow chimeras, indicated that rapid protective Th1 responses required both PP and MLN. Moreover, the timing of Th1 induction in both MLN and gut was dependent on the presence of PP suggesting a level of cooperation between immune responses induced in these distinct lymphoid structures. The delay in Th1 induction was attributable to the delayed arrival of a broad range of dendritic cell subsets in the MLN and a substantial reduction of CD8alpha(-)CD11b(high) B220(-) dendritic cells in PP-deficient mice.

Original publication

DOI

10.4049/jimmunol.176.12.7533

Type

Journal article

Journal

J Immunol

Publication Date

15/06/2006

Volume

176

Pages

7533 - 7541

Keywords

Animals, Cell Differentiation, Cell Movement, Coccidiosis, Dendritic Cells, Eimeria, Intestinal Diseases, Parasitic, Intestinal Mucosa, Kinetics, Lymph Nodes, Lymphocyte Activation, Lymphotoxin-alpha, Lymphotoxin-beta, Membrane Proteins, Mesentery, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Peyer's Patches, Th1 Cells