Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

© Springer Science+Business Media B.V. 2010. All Rights Reserved. T lymphocytes traffic through tissues by different modes of amoeboid motility while scanning for antigenic peptides presented on the surface of Antigen-Presenting Cells (APCs). Effective T-Cell Receptor (TCR T Cell Receptor TCR) signaling, upon recognition of a peptide, leads to the formation of a cell-cell junction between the T lymphocyte and the APC Antigen Presenting Cell APC. This junction has been termed as the immunological synapse (when it is radially symmetric and stable) or as the immunological kinapse (when it is asymmetric and mobile). Well-regulated coordination between the migratory behavior of T cells and the dynamics of immunological synapse is important for all the major facets of adaptive immune response. In this chapter we discuss how the actin cytoskeleton mediates this coordination by serving as a crucial platform for integrating and influencing signals from the TCR T Cell Receptor TCR, adhesion and chemokine receptors. We also highlight key experimental approaches that have shaped our current understanding on the role of the actin cytoskeleton in the dynamics of the synapses and kinapses.

Original publication

DOI

10.1007/978-90-481-9301-1_5

Type

Chapter

Book title

Actin-based Motility: Cellular, Molecular and Physical Aspects

Publication Date

01/01/2010

Pages

103 - 124