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Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

Original publication

DOI

10.15252/embj.201796697

Type

Journal article

Journal

The EMBO Journal

Publication Date

07/2017

Volume

36

Pages

1811 - 1836

Addresses

Université Paris Descartes/Paris V, Paris, France.

Keywords

Animals, Mice, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Autophagy, Gene Regulatory Networks, Terminology as Topic