Room 5804, Level 5, John Radcliffe Hospital
Oxford, OX3 9DU
Research Facilitator for Immunology
I am responsible for coordinating and communicating immunology-related research across the Medical Sciences Division. Immunology research encompasses a wide range of subjects including the defence against infection, inflammatory diseases, cancer, therapeutics, and many others. Similarly, researchers are spread across a number of sites and departments within the University. The Immunology Network aims to promote the sharing of ideas, expertise and resources within Oxford, and to facilitate collaborations, identify funding opportunities and support research innovation.
Prior to starting this role I worked as a post-doctoral scientist at the University of Oxford for twelve years, initially at the Weatherall Institute of Molecular Medicine using biochemical assays to understand more about the cancer-predisposition disorder Bloom’s Syndrome, and subsequently at the Structural Genomics Consortium where I used cell-based assays to validate potential drug-like molecules in the treatment of the rare bone disease Fibrodysplasia Ossificans Progressiva (FOP), also known as Stone Man Syndrome.
A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis
Kerr G. et al, (2015), Angiogenesis, 18, 209 - 217
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Nguyen GH. et al, (2013), Chem Biol, 20, 55 - 62
A new class of small molecule inhibitor of BMP signaling.
Sanvitale CE. et al, (2013), PLoS One, 8
Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva
Chaikuad A. et al, (2012), Journal of Biological Chemistry, 287, 36990 - 36998
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.
Suhasini AN. et al, (2011), EMBO J, 30, 692 - 705