Nicole Horwood

Associate Professor and ARUK Senior Research Fellow

Associate Professor Horwood is the Principal Investigator of the Osteoimmunology Research group at The Kennedy Institute of Rheumatology, NDORMS, University of Oxford.

She completed her PhD on osteoclast differentiation in 1999 at St Vincent’s Institute, University of Melbourne. She was subsequently awarded the Victoria Premiers Commendation for Medical Research in 2000 as well as a Howard Florey fellowship from the Royal Society for postdoctoral studies at the Kennedy Institute, Imperial College London with Professor Sir Marc Feldmann and Professor Brian Foxwell.

She was appointed to a lectureship in 2004 and is now an associate professor with The University of Oxford.

She is currently a Senior Research Fellow of Arthritis Research UK. Current research projects investigate links between bone cell function and multiple myeloma, inflammation and fracture repair, factors controlling osteoblast dedifferentiation, and mechanisms of new bone formation in ankylosing spondylitis and osteoarthritis.

Key publications

Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss.
Journal article

Espirito Santo AI. et al, (2015), Biochem Biophys Res Commun, 464, 1145 - 1150
Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
Journal article

Ersek A. et al, (2015), J Clin Invest, 125, 2279 - 2292
Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation.
Journal article

Nicolaidou V. et al, (2012), PLoS One, 7
Dual-specificity phosphatase-1 null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis
Journal article

Vattakuzhi Y. et al, (2012), Arthritis and Rheumatism, 64, 2201 - 2210
Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo.
Journal article

Lymperi S. et al, (2011), Blood, 117, 1540 - 1549

Recent publications

HMGB1 accelerates regeneration of multiple tissues by transitioning stem cells to G(Alert)
Conference paper

Lee G. et al, (2018), AUSTRALASIAN JOURNAL OF DERMATOLOGY, 59, 83 - 83
Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G(alert)
Journal article

Lee G. et al, (2018), Proceedings of the National Academy of Sciences
HMGB1 accelerates regeneration of multiple tissues by transitioning stem cells to G(Alert)
Conference paper

Lee G. et al, (2017), JOURNAL OF BONE AND MINERAL RESEARCH, 32, S48 - S48
NOVEL MODELS OF LATE ONSET, PROGRESSIVE OSTEOARTHRITIS CAUSED BY POINT MUTATIONS IN THE TWO ALPHA CHAINS OF COLLAGEN TYPE I
Conference paper

Blease AM. et al, (2017), OSTEOARTHRITIS AND CARTILAGE, 25, S56 - S56
Macrophage Polarization and Bone Formation: A review.
Journal article

Horwood NJ., (2016), Clin Rev Allergy Immunol, 51, 79 - 86

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