A comprehensive analysis of recovered COVID-19 patients and dynamic trend in antibodies over 3 months using ELISA and CLIA methods
Cardiff University review immunology/immunity
First Author: Puya Dehgani-Mobaraki,
Journal/preprint name: medrxiv
Paper DOI: https://doi.org/10.1101/2020.08.31.20184838
Tags: Antibody trends over time
Summary
This study investigated the antibody response and duration of COVID-19 patients over a three-month period. Patients were invited for serological tests spaced at least 2 weeks apart and the authors used ELISA and CLIA to determine antibody levels.
Research Highlights
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The mean duration of viral shedding: 20.13 ± 6.17 days (median of 21 days)
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Comorbidities present included hypertension, diabetes, coronary heart disease and asthma
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Most common symptoms were fever, altered sense of smell and taste, muscle pain and sore throat
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Antibody trends were similar at both time points
Methodologies:
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Study Type: Cohort Study
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Key Techniques: ELISA and CLIA
Limitations:
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Small sample size of only 30 patients
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Only one follow up time
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Follow up time was not consistent between patients
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A mean value of 53 days, does not equate to a follow up of three months
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Results are very different between methods
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Did not investigate the relationship between antibody titre and neutralizing activity