Coronavirus disease 2019 induced inflammatory response are associated with changes in lipid profiles
inflammation
First Author: Chuanwei Li et al
Journal/preprint name: Research Square
Paper DOI: 10.21203/rs.3.rs-64766/v1
Tags: Lipid, lipoprotein, cytokine, inflammation
Summary
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In this study Chuanwei Li et al evaluate the effects of Covid-19 on the lipoprotein profiles as it has been demonstrated previously that there is an association between changes in lipids and lipoprotein and viral pneumonia.
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This is the first preliminary study descriptively evaluating the effects of Covid-19 on 242 different patients between 53-69 in Wuhan.
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This study shows that patients with covid-19 exhibit atherogenic lipid changes which might correlate with exuberant inflammatory responses.
Research Highlights
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Marked decrease in serum levels of HDL-c and apoA-I in Covid-19 patients
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Consistent with the decrease in apoA-I and increase in apoB, the apoB/apoA-1 ratio, which worked as indices for risk of acute myocardial infarction, were notable increased
Impact for COVID-19 research:
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As is it shown in this study, patients with covid-19 show a lipid profile different to healthy patients which could be correlated with exuberant inflammatory responses
Methodologies:
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Study Type: cohort study.
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Key Techniques: Biochemical measurements and lipid profiles including total cholesterol, high density lipoprotein, low density lipoprotein cholesterol, non-high density lipoprotein cholesterol, apoA-1 and apoB.
Limitations:
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No data recorded after the recovery of patients
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No data regarding the viral load to check whether it exists a correlation between the viral load, cytokine storm and lipid levels.