Coronavirus disease 2019 induced inflammatory response are associated with changes in lipid profiles
First Author: Chuanwei Li et al
Journal/preprint name: Research Square
Paper DOI: 10.21203/rs.3.rs-64766/v1
Tags: Lipid, lipoprotein, cytokine, inflammation
In this study Chuanwei Li et al evaluate the effects of Covid-19 on the lipoprotein profiles as it has been demonstrated previously that there is an association between changes in lipids and lipoprotein and viral pneumonia.
This is the first preliminary study descriptively evaluating the effects of Covid-19 on 242 different patients between 53-69 in Wuhan.
This study shows that patients with covid-19 exhibit atherogenic lipid changes which might correlate with exuberant inflammatory responses.
Marked decrease in serum levels of HDL-c and apoA-I in Covid-19 patients
Consistent with the decrease in apoA-I and increase in apoB, the apoB/apoA-1 ratio, which worked as indices for risk of acute myocardial infarction, were notable increased
Impact for COVID-19 research:
As is it shown in this study, patients with covid-19 show a lipid profile different to healthy patients which could be correlated with exuberant inflammatory responses
Study Type: cohort study.
Key Techniques: Biochemical measurements and lipid profiles including total cholesterol, high density lipoprotein, low density lipoprotein cholesterol, non-high density lipoprotein cholesterol, apoA-1 and apoB.
No data recorded after the recovery of patients
No data regarding the viral load to check whether it exists a correlation between the viral load, cytokine storm and lipid levels.