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First Author:  S Keddie 

Journal/preprint name: medRxiv 

Tags: Cytokines, biomarker, intensive care IL-6, CRP, IL-10, LDH. 

Summary 

  • S Keddie et al study which englobes 100 patients of COVID-19 investigates the routine laboratory test and cytokines implicated in the disease for their potential application as biomarkers of disease severity, respiratory failure and need of higher-level care. Demonstrating the importance of IL-6, CRP, IL-10, LDH and TNF-α as biomarkers in different aspects of COVID-19, supporting other studies previously done. 

Research Highlights 

  1.  IL-6 and CRP were most significantly indicative of the level of respiratory support 

  1. IL-1β is the only biomarker which significantly differentiated by gender, with higher levels in males 

  1. IL-1β did not correlate with severity measures presence of ARDS or level of respiratory support 

Impact for COVID-19 research:  

  • This study consists in brief cohort of different biomarkers that could help to classify patient according to the severity of illness. Although it supports other previous studies. 

Methodologies: 

  • Study Typecohort study. 

  • Key Techniques: four-PLEX cytokine ELISA-based electrochemoluminiscent immunoassay to measure IL-6, IL-1β, IL-10 and TNF-α. 

Limitations: 

  • The number of patient is 100 of which only 86% was confirmed by PCR. The rest were considered based on internationally recognized diagnostic criteria. 

  • The only technique used in the study to check the levels of biomarkers is an ELISA. Although it is efficient might have been worth it to also corroborate by using other techniques