Researchers at the University of Cambridge and the University of Oxford have discovered a new molecule that plays a key role in the immune response that is triggered by influenza infections.
What does it mean to be poor in the UK and around the world? Could we eliminate this kind of inequality or is it an unavoidable part of society? This needs a lot more thought...
Researchers from the WHG, lead by centre PI Prof. Ross Chapman, have published their research in Nature which describes the discovery of the Shieldin complex, a single-stranded DNA-binding repair complex that is essential for context-dependent DNA repair events in the immune system and cancer.
Researchers have reported the results of the first randomised clinical trial to test a novel strategy. The approach involves waking up and then killing the \u2018sleeping\u2019 HIV that is hiding in the body using an experimental approach known as \u2018kick and kill\u2019.
Activation of the bacteria-sensing NOD receptors triggers inflammatory signalling via Receptor-interacting protein kinase 2 (RIPK2). Since RIPK2 inhibitors targeting the ATP-binding pocket have been shown to block this signalling pathway, it was assumed that RIPK2 kinase activity was important for signal transmission. In this work published recently in EMBO Journal, Hrdinka, Schlicher and colleagues from Mads Gyrd-Hansen\u2019s lab demonstrate that kinase activity is in fact dispensable for NOD signalling and that these RIPK2 inhibitors are instead preventing the binding of the ubiquitin ligase, XIAP, and the subsequent XIAP-mediated ubiquitination of RIPK2 necessary for downstream signalling. This work could have therapeutic implications since NOD signalling is associated with several chronic inflammatory conditions such as Crohn\u2019s disease.
A team of malaria experts from a large international research collaboration has today published results supporting the need for a radical cure strategy to tackle one of the most debilitating forms of malaria caused by the Plasmodium vivax parasite.
A collaborative study between the Kennedy Institute and MRC Weatherall Institute of Molecular Medicine (MRC WIMM) identifies a new pathway that limits the severity of inflammatory skin disease.
Oxford Mathematician Ruth Baker and Antoine Jerusalem from Oxford's Department of Engineering argue that the research community should embrace the complementary strengths of mechanistic modelling and machine learning approaches to provide, for example, the missing link between patient outcome prediction and the mechanistic understanding of disease progression.
The benefits of antibiotics to both human and animal health are undisputed. However, as microbes have become increasingly resistant to antimicrobials and other drugs, scientists have become interested in new solutions to the growing superbug crisis, including the use of defensive microbes and faecal transplants. In new research, Oxford University scientists have developed a lab-based approach, creating positive co-dependent relationships between hosts and bacteria, termed \u2018mutualisms\u2019, quickly. These lab-developed bacterial relationships demonstrate how microbes can work with their hosts to prevent infection.
Kennedy researchers and Columbia University engineers discover geometric underpinnings of T-cell stimulation through precise engineering of T-cell receptor geometry, building a 3D nanofabricated biomimetic surface that simulates the key components of an antigen-presenting cell.
![\"\"](\"https://www.immunology.ox.ac.uk/news/influenza-virus-molecules-set-immune-response-into-overdrive/responsive_image?ratio=r16x9&scale=w760\")
\n \n \n\n\n