Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally active adenovirus vector genomes at the site of inoculation, in liver, and lymphatic tissues. Continuously produced small amounts of antigen maintain fully active effector CD8(+) T cells, while also allowing for their differentiation into central memory cells. The long-term persistence of adenoviral vectors may be highly advantageous for their use as vaccines against pathogens for which T-cell-mediated protection requires both fully activated T cells for immediate control of virus-infected cells and central memory CD8(+) T cells that, because of their higher proliferative capacity, may be suited best to eliminate cells infected by pathogens that escaped the initial wave of effector T cells.

Original publication

DOI

10.1182/blood-2007-02-062117

Type

Journal article

Journal

Blood

Publication Date

15/09/2007

Volume

110

Pages

1916 - 1923

Keywords

Adenoviridae, Adenoviridae Infections, Animals, Antigens, Viral, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cells, Cultured, Chromium, Egg Proteins, Gene Products, gag, Genetic Vectors, Glycoproteins, Green Fluorescent Proteins, HeLa Cells, Humans, Immunization, Immunologic Memory, Kidney, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Ovalbumin, Peptide Fragments, Primates, T-Lymphocytes, Viral Vaccines