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We administered bromocriptine (Parlodel) to arthritic mice immediately postpartum, and found that the drug suppressed the clinical exacerbation of joint involvement that was seen in untreated animals. Approximately 50% reduction in severity of disease was achieved with bromocriptine (P less than 0.001). The effect may be due to suppression of the prolactin release that normally occurs postpartum.

Original publication

DOI

10.1002/art.1780310717

Type

Journal article

Journal

Arthritis Rheum

Publication Date

07/1988

Volume

31

Pages

927 - 928

Keywords

Animals, Arthritis, Bromocriptine, Collagen, Female, Mice, Postpartum Period, Pregnancy