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We measured CD8(+) T-cell responses in 12 potentially exposed but uninfected men who have sex with men by using cytokine flow cytometry. Four of the individuals screened exhibited polyfunctional immune responses to human immunodeficiency virus type 1 Gag or Vif. The minimum cytotoxic T lymphocyte epitope was mapped in one Gag responder.

Original publication

DOI

10.1128/CVI.00247-08

Type

Journal article

Journal

Clin Vaccine Immunol

Publication Date

11/2008

Volume

15

Pages

1745 - 1748

Keywords

CD8-Positive T-Lymphocytes, Cytokines, Epitope Mapping, Epitopes, T-Lymphocyte, HIV Infections, HIV-1, Homosexuality, Male, Humans, Male, gag Gene Products, Human Immunodeficiency Virus, vif Gene Products, Human Immunodeficiency Virus