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BACKGROUND: The HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele. METHODOLOGY/PRINCIPAL FINDINGS: Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ individuals. Subjects expressing HLA-B*35-Px alleles showed no difference in response to the consensus epitopes compared to individuals with HLA-B*35-Py alleles. Surprisingly, all the HLA-B*35-Px+ individuals responded to epitope-variants even in the absence of a consensus response. Sequencing of the viral population revealed no evidence of variant virus in any of the individuals. CONCLUSIONS/SIGNIFICANCE: This demonstrates a novel phenomenon that distinguishes individuals with the HLA-B*35-Px rapid progressing allele and those with the HLA-B*35-Py slower progressing allele.

Original publication

DOI

10.1371/journal.pone.0010249

Type

Journal article

Journal

PLoS One

Publication Date

21/04/2010

Volume

5

Keywords

Alleles, CD4 Lymphocyte Count, CD8-Positive T-Lymphocytes, Disease Progression, Epitopes, T-Lymphocyte, Genetic Variation, HIV Infections, HIV-1, HLA-B35 Antigen, Humans, Longitudinal Studies, T-Cell Antigen Receptor Specificity, T-Lymphocytes, Cytotoxic, Viral Load