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Understanding human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T-lymphocyte responses is important for the development of vaccines and therapies. We describe a novel method for the rational selection of peptides that target stable regions of the HIV-1 genome, rich in epitopes specifically recognized by the study population. This method will be of particular use under resource/sample-limited conditions.

Original publication

DOI

10.1128/CVI.00048-07

Type

Journal article

Journal

Clin Vaccine Immunol

Publication Date

06/2007

Volume

14

Pages

785 - 788

Keywords

Amino Acid Sequence, Epitopes, Genome, Viral, HIV-1, Humans, Molecular Sequence Data, Peptides, Selection, Genetic, T-Lymphocytes, Cytotoxic