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Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pK(a) vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pK(a) analogues.

Original publication

DOI

10.1039/b803262a

Type

Journal article

Journal

Mol Biosyst

Publication Date

07/2008

Volume

4

Pages

741 - 745

Keywords

DNA, Disulfides, Gene Transfer Techniques, Genetic Vectors, Kinetics, Microscopy, Atomic Force, Peptides