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Real-time atomic force microscopy (AFM) in aqueous buffer has been used to probe interactions of synthetic disulfide-linked polypeptide gene delivery vectors with supported phospholipid bilayers. Disruption of the membranes was apparent in AFM, and the extent of surface heterogeneity and hole (pore) formation was evaluated by depth and area-profiling image analysis. The overall extent of membrane disruption varied with the reducible polycation peptide sequence and block structure and was found to be correlated with the overall degree of transgene expression in two representative cell lines. © 2010 The Royal Society of Chemistry.

Original publication

DOI

10.1039/b927204f

Type

Journal article

Journal

Soft Matter

Publication Date

07/06/2010

Volume

6

Pages

2517 - 2524