Biologics in Asthma: Role of Biomarkers.

Lavoie G., Pavord ID.

Our modern understanding of asthma mainly concerns identification of inflammatory endotype to guide management. The distinction mostly concerns identification of type-2 inflammation, for which different biomarkers have been well characterized. Blood eosinophils corroborate activity in the interleukin (IL)-5 axis while fraction of exhaled nitric oxide is indicative of the IL-4/IL-13 axis, giving us an indication of activity in these distinct but complementary pathways. These biomarkers predict disease activity, with increased risk of exacerbations when elevated, and a further, multiplicative increase when both are elevated. Serum immunoglobulin E is also implicated in this pathway, and can represent allergen-related stimulation.

DOI

10.1016/j.iac.2024.08.003

Type

Journal article

Journal

Immunol Allergy Clin North Am

Publication Date

11/2024

Volume

44

Pages

709 - 723

Keywords

Asthma, Biomarker, Inflammation, Management, Severe, Humans, Asthma, Biomarkers, Biological Products, Immunoglobulin E, Eosinophils, Anti-Asthmatic Agents, Cytokines

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