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Highly active antiretroviral therapy (HAART) has transformed HIV-1 infection from an invariably fatal disease into a chronic infection requiring lifelong treatment. However, the challenges we still face are the urgent need to provide affordable sustainable therapy to the millions of infected individuals who live in resource-poor countries, and the limitations posed by serious drug toxicity and viral resistance associated with long-term therapy. Augmentation of HIV-specific immunity by therapeutic vaccination is a possible alternative to continuous HAART. In this review, progress in the development of therapeutic immunization strategies is discussed.

Original publication

DOI

10.1258/095646206777689035

Type

Journal article

Journal

Int J STD AIDS

Publication Date

07/2006

Volume

17

Pages

436 - 441

Keywords

AIDS Vaccines, Animals, Dendritic Cells, HIV Infections, HIV-1, Humans, Immunization, Vaccines, DNA