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Colorectal cancer (CRC) is one of the best characterised cancers, with extensive data documenting the sequential gene mutations that underlie its development. Complementary datasets are also being generated describing changes in protein and RNA expression, tumour biology and clinical outcome. Both the quantity and the variety of information are inexorably increasing and there is now an accompanying need to integrate these highly disparate datasets. In this article we aim to explain why we believe that mathematical modelling represents a natural tool or language with which to integrate these data and, in so doing, to provide insight into CRC.

Original publication

DOI

10.3748/wjg.v13.i9.1399

Type

Journal article

Journal

World J Gastroenterol

Publication Date

07/03/2007

Volume

13

Pages

1399 - 1407

Keywords

Apoptosis, Cell Differentiation, Cell Movement, Cell Proliferation, Colorectal Neoplasms, Humans, Models, Theoretical, Signal Transduction, Stochastic Processes