Macrophage-tumour interactions: In vivo dynamics

Experimentalists are developing new therapies that exploit the tendency of macrophages, a type of white blood cell, to localise within solid tumours. The therapy studied here involves engineering macrophages to produce chemicals that kill tumour cells. Accordingly, a simple mathematical model is developed that describes interactions between normal cells, tumour cells and infiltrating macrophages. Numerical and analytical techniques show how the ability of the engineered macrophages to eliminate the tumour changes as model parameters vary. The key parameters are m*, the concentration of engineered macrophages injected into the vasculature, and k1, the rate at which they lyse tumour cells. As k1or m* increases, the average tumour burden decreases although the tumour is never completely eliminated by the macrophages. Also, the stable solutions are oscillatory when k1and m* increase through well-defined bifurcation values. The physical implications of our results and directions for future research are also discussed.