Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We present a theoretical study of superficial bladder cancer growth and its treatment via pulsed immunotherapy with Bacillus Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis. BCG pulsed immunotherapy is a clinically established procedure for the treatment of superficial bladder cancer. In this paper, periodic BCG instillations are modeled using impulsive differential equations, which are studied using a combination of analytical and numerical techniques. In this way, we determine critical threshold values of the BCG instillation dose and rate of pulsing for successful treatment. We also identify treatment regimes in which tumor destruction occurs, but undesirable side effects are maintained at low levels by the immune system.

Original publication

DOI

10.1007/s11538-008-9344-z

Type

Journal article

Journal

Bull Math Biol

Publication Date

10/2008

Volume

70

Pages

2055 - 2076

Keywords

Administration, Intravesical, Algorithms, Carcinoma, Transitional Cell, Computer Simulation, Humans, Immunotherapy, Active, Models, Biological, Mycobacterium bovis, Treatment Outcome, Urinary Bladder Neoplasms