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It is clear that latent CMV can reactivate in immunocompetent individuals, but the mechanism triggering such reactivations remains unclear. Recent clinical data suggest that reactivation can be subverted by CMV-specific T-memory. We therefore monitored CMV-specific T cells in immunocompetent mice with latent mCMV after a known reactivation trigger (LPS). LPS induced transient systemic contraction of mCMV-specific CD8 memory that was followed by transcriptional reactivation. Subsequent recovery of mCMV-specific T cells coincided with resumption of latency. These data suggest that bacterial antigen encounters can induce transient T-memory contraction, allowing viral recrudescence in hosts latently infected with herpes family viruses.

Original publication

DOI

10.1189/jlb.1211635

Type

Journal article

Journal

J Leukoc Biol

Publication Date

11/2012

Volume

92

Pages

933 - 937

Keywords

Animals, Antigens, Bacterial, CD8-Positive T-Lymphocytes, Cytomegalovirus, Cytomegalovirus Infections, Female, Flow Cytometry, Immunologic Memory, Lipopolysaccharides, Mice, Mice, Inbred BALB C, Reverse Transcriptase Polymerase Chain Reaction, Virus Activation, Virus Latency