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Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolutionary history of the malaria-protective alleles HbS and HbC in the Kassena-Nankana District (KND) of Ghana.

Original publication

DOI

10.1371/journal.pone.0034565

Type

Journal article

Journal

PloS one

Publication Date

01/2012

Volume

7

Pages

e34565 - e34565