Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.
Ghansah A., Rockett KA., Clark TG., Wilson MD., Koram KA., Oduro AR., Amenga-Etego L., Anyorigiya T., Hodgson A., Milligan P., Rogers WO., Kwiatkowski DP.
Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolutionary history of the malaria-protective alleles HbS and HbC in the Kassena-Nankana District (KND) of Ghana.