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BACKGROUND: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a common sleep disorder that can be associated with a number of neurodegenerative conditions as well as with narcolepsy. Current diagnostic criteria require overnight polysomnography, and there are no other biomarkers available. The control of REM sleep is complex with a putative on/off switch within the brainstem activated, amongst other things, by hypocretinergic pathways from the lateral hypothalamus. METHODS: Cerebrospinal fluid hypocretin levels were measured in five patients with idiopathic RBD. RESULTS: Hypocretin levels were between 254 and 450 pg/ml and therefore within the normal range of >100 pg/ml. CONCLUSION: Hypocretin levels in patients with idiopathic RBD are normal.

Original publication




Journal article


Eur J Neurol

Publication Date





1105 - 1107


Aged, Female, Humans, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, Neuropeptides, Orexins, REM Sleep Behavior Disorder