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Chronic, non-communicable diseases are the major cause of death and disability worldwide and have replaced infectious diseases as the major burden of society in large parts of the world. Despite the complexity of chronic diseases, relatively few predisposing risk factors have been identified by the World Health Organization. Those include smoking, alcohol abuse, obesity, high cholesterol and high blood pressure as the cause of many of these chronic conditions. Here, we discuss several examples of vaccines that target these risk factors with the aim of preventing the associated diseases and some of the challenges they face.

Original publication

DOI

10.1098/rstb.2011.0103

Type

Journal article

Journal

Philos Trans R Soc Lond B Biol Sci

Publication Date

12/10/2011

Volume

366

Pages

2815 - 2822

Keywords

Angiotensin II, Animals, Antibodies, Antibody Formation, Antihypertensive Agents, Chronic Disease, Diabetes Mellitus, Type 2, Humans, Hypertension, Interleukin-1beta, Mice, Nicotine, Risk Factors, Smoking, Smoking Cessation, Vaccination, Vaccines, Vaccines, Virus-Like Particle