Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells but not in B cells to enhance the TD antibody response, regardless of the inherent immunogenicity of the antigen. In contrast, a TLR9 ligand contained within a virus-like particle substantially augmented the TD germinal center IgG antibody response, and this augmentation required B cell MyD88. The ability of B cells to discriminate between antigens based on the physical form of a TLR ligand probably reflects an adaptation to facilitate strong antiviral antibody responses.

Original publication

DOI

10.1016/j.immuni.2011.01.011

Type

Journal article

Journal

Immunity

Publication Date

25/03/2011

Volume

34

Pages

375 - 384

Keywords

Animals, Antibodies, Viral, B-Lymphocytes, Dendritic Cells, Germinal Center, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Immunological, Myeloid Differentiation Factor 88, Orthomyxoviridae, Signal Transduction, Toll-Like Receptor 9