Cytokines are key instigators and regulators of immune responses and therefore hold great potential as targets for new therapeutic strategies. However, the selection of which cytokines to target, and in particular the identification of which cytokines regulate the rate-limiting steps of disease pathways, is crucial to the success of such strategies. Moreover, balancing the need for ablating pathological inflammatory responses and simultaneously maintaining the ability to control infectious agents is a key consideration. Recent advances in our understanding of cytokine networks, as well as technical progress in blocking cytokines in vivo, are likely to be a source for new drugs that can control chronic inflammatory diseases.

Original publication

DOI

10.1038/nrd2805

Type

Journal article

Journal

Nat Rev Drug Discov

Publication Date

09/2010

Volume

9

Pages

703 - 718

Keywords

Animals, Chronic Disease, Cytokines, Drug Delivery Systems, Drug Design, Humans, Inflammation