Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Viruses induce excellent antibody responses due to several intrinsic features. Their repetitive, organised structure is optimal for the activation of the B cell receptor (BCR), leading to an increased humoral response and a decreased dependence on T cell help. Viruses also trigger Toll-like receptors (TLRs), which in addition to increasing overall Ig levels, drive the switch to the IgG2a isotype. This isotype is more efficient in viral and bacterial clearance and will activate complement, which in turn lowers the threshold of BCR activation. Exploiting these characteristics in vaccine design may help us to create vaccines which are as safe as a recombinant vaccine yet still as effective as a virus in inducing B cell responses.

Type

Journal article

Journal

Curr Top Microbiol Immunol

Publication Date

2008

Volume

319

Pages

1 - 15

Keywords

Animals, Antigens, Viral, B-Lymphocytes, Complement Activation, Epitopes, Humans, Lymphocyte Activation, Receptors, Antigen, B-Cell, Signal Transduction, T-Lymphocyte Subsets, Toll-Like Receptors, Viral Vaccines