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OX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implicated in stimulation of T cells and T-dependent humoral responses. We generated OX40-/- mice and found that the formation of extrafollicular plasma cells, germinal centers, and antibody responses was independent of OX40. After infection with LCMV and influenza virus, OX40-/- mice retain primary and memory cytotoxic T cell responses with normal expansion and decline of specific CTL. In contrast, CD4+ T cell proliferation and the number of IFN-gamma-producing CD4+ T cells were reduced in OX40-/- mice. Moreover, the number of CD4+ T cells infiltrating the lungs of influenza virus-infected OX40-/- mice was reduced. These results define a unique role of OX40 in the generation of optimal CD4+ T cell responses in vivo.

Type

Journal article

Journal

Immunity

Publication Date

12/1999

Volume

11

Pages

699 - 708

Keywords

Animals, Antibodies, Viral, B-Lymphocytes, CD4-Positive T-Lymphocytes, Cell Division, Cell Line, Dogs, Female, Humans, Influenza A virus, Lymphocytic choriomeningitis virus, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, OX40, Receptors, Tumor Necrosis Factor, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Helper-Inducer, Tumor Necrosis Factor Receptor Superfamily, Member 7, Vesicular stomatitis Indiana virus, Virus Diseases