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Neutralizing antiviral B cell responses differ in various aspects from the many usually measured B cell responses specific for protein in adjuvants. In particular, such neutralizing antiviral B cell responses are more rapidly induced, reach higher titers, are longer lived, and are efficiently generated without adjuvants. Evidence is summarized here that the repetitiveness of many viral antigens is a key factor responsible for the efficiency of these B cell responses, amplifying B cells early and rapidly for potent IgM responses and also for efficient switching to IgG. The data reviewed indicate that B cells discriminate antigen patterns via the degree of surface Ig-cross-linking and use antigen repetitiveness as a self/nonself discriminator.

Original publication

DOI

10.1146/annurev.immunol.15.1.235

Type

Journal article

Journal

Annu Rev Immunol

Publication Date

1997

Volume

15

Pages

235 - 270

Keywords

Animals, Antibodies, Viral, Antigens, Viral, B-Lymphocytes, Humans, Immunologic Memory, Lymphocyte Activation, Lymphocyte Cooperation, Membrane Glycoproteins, Models, Biological, Neutralization Tests, Signal Transduction, T-Lymphocytes, Vesicular stomatitis Indiana virus, Viral Envelope Proteins, Virus Diseases