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Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

Type

Journal article

Journal

Science

Publication Date

02/06/1995

Volume

268

Pages

1343 - 1347

Keywords

Animals, Antigen-Presenting Cells, Cytotoxicity, Immunologic, Fibroblasts, Glycoproteins, Histocompatibility Antigens Class I, L Cells (Cell Line), Lymphocytic Choriomeningitis, Lymphocytic choriomeningitis virus, Lymphoid Tissue, Mice, Mice, Inbred C57BL, Neoplasms, T-Lymphocytes, Cytotoxic, Transfection, Tumor Cells, Cultured, Viral Proteins