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As mice deficient in a particular gene provide an increasing number of novel in vivo models, in vivo assays that examine immune function are becoming a central issue. We found that the sensitivities of in vivo and in vitro assays are strikingly different. These differences have important implications for the interpretation and biological relevance of results.


Journal article


Curr Opin Immunol

Publication Date





320 - 326


Animals, B-Lymphocytes, Immunologic Tests, In Vitro Techniques, Mice, Mice, Knockout, Sensitivity and Specificity, T-Lymphocytes, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Helper-Inducer