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The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.

Type

Journal article

Journal

Science

Publication Date

26/11/1993

Volume

262

Pages

1448 - 1451

Keywords

Animals, Antibodies, Viral, Antibody Affinity, B-Lymphocytes, Immune Tolerance, Immunization, Immunoglobulin G, Immunoglobulin M, Lymphocyte Activation, Macrophages, Peritoneal, Membrane Glycoproteins, Mice, Mice, Transgenic, Neutralization Tests, T-Lymphocytes, Helper-Inducer, Vesicular stomatitis Indiana virus, Viral Envelope Proteins