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Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.


Journal article


J Virol

Publication Date





3680 - 3683


Animals, Antibodies, Viral, Antigens, Viral, B-Lymphocytes, CD4 Antigens, CD8 Antigens, Capsid, Epitopes, H-2 Antigens, Membrane Glycoproteins, Mice, Mice, Inbred Strains, T-Lymphocyte Subsets, T-Lymphocytes, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Helper-Inducer, Vesicular stomatitis Indiana virus, Viral Core Proteins, Viral Envelope Proteins, Virus Diseases