Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Molecular mimicry has been considered to be one of the potential mechanisms underlying the induction of autoimmune diseases. Using a TCR-transgenic model specific for lymphocytic choriomeningitis virus (LCMV) we have examined the potential for cross-reactive recognition of tissue-restricted self peptides. Several peptides were identified that were able to cross-react with the TCR-transgenic virus-specific T cells in vitro. One peptide was derived from dopamine beta-mono-oxygenase, an enzyme expressed in the adrenal medulla. Interestingly, after activation of the transgenic T cells with LCMV glycoprotein peptides or viruses, infiltration of the adrenal medulla was detected in conjunction with alterations in dopamine metabolism. However, complete destruction of the adrenal medulla was not observed. This suggests that molecular mimicry may be sufficient for self recognition and infiltration, but other factors clearly contribute to chronic autoimmune disease.

Original publication

DOI

10.1002/(SICI)1521-4141(199909)29:09<2886::AID-IMMU2886>3.0.CO;2-A

Type

Journal article

Journal

Eur J Immunol

Publication Date

09/1999

Volume

29

Pages

2886 - 2896

Keywords

Allergens, Animals, Autoimmunity, Cross Reactions, DNA-Binding Proteins, Epitopes, H-2 Antigens, Ligands, Lymphocytic choriomeningitis virus, Mice, Mice, Congenic, Mice, Inbred C57BL, Mice, Transgenic, Molecular Mimicry, Receptors, Antigen, T-Cell, Tumor Cells, Cultured