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Dendritic cells (DCs) exhibit considerable heterogeneity in their anatomical location, surface phenotype, and functional properties. In this study, we demonstrate that peripheral lymph nodes contain at least four major, functionally separable, and independently derived, DC subsets, which can be clearly demarcated by their CD11c, CD40, and CD8 expression pattern. Surprisingly, all DCs derived directly from the bone marrow, the myeloid- and the lymphoid-related subsets, turned over fast with t(1/2) of a couple of days. In contrast, DCs exported from the skin, both dermal and epidermal, accumulated 3- to 4-fold slower, turnover that is dramatically increased by cutaneous inflammation.

Original publication

DOI

10.4049/jimmunol.165.9.4910

Type

Journal article

Journal

J Immunol

Publication Date

01/11/2000

Volume

165

Pages

4910 - 4916

Keywords

Administration, Cutaneous, Animals, Cell Lineage, Cell Movement, Cell Separation, Cell Survival, Dendritic Cells, Immunophenotyping, Lymph Nodes, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Organ Culture Techniques, Organ Specificity, Peptides, Skin, Skin Tests, T-Lymphocytes