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T-cell specificity is encoded in single T-cell receptors (TCRs) but monovalent interactions with peptide bound to the major histocompatibility complex (MHC) may not sufficiently account for the complexities associated with T-cell activation. This review proposes that TCRs undergo dimerization before activation and that this property might be essential for both T-cell antagonism and T-cell specificity, and may be pivotal for T-cell survival versus T-cell activation.


Journal article


Immunol Today

Publication Date





568 - 576


Animals, Dimerization, Endocytosis, Ligands, Lymphocyte Activation, Models, Immunological, Peptide Fragments, Rats, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Cytotoxic