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Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been suggested to induce tolerance. Here we show that both subsets activate CD8(+) T cells in vitro and induce protective anti-viral CTL responses in vivo. Thus, vaccine strategies using peptide-pulsed DC do not have to take into account DC subsets for priming.

Original publication

DOI

10.1002/(SICI)1521-4141(199911)29:11<3762::AID-IMMU3762>3.0.CO;2-F

Type

Journal article

Journal

Eur J Immunol

Publication Date

11/1999

Volume

29

Pages

3762 - 3767

Keywords

Animals, CD8 Antigens, Dendritic Cells, Immunophenotyping, Lymph Nodes, Mice, Mice, Inbred C57BL, Spleen, T-Lymphocytes, Cytotoxic