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Mice deficient for the expression of CTLA-4 develop a lethal lymphoproliferative syndrome and multiorgan inflammation leading to death at about 4 wk of age. Here we show that RAG2-deficient mice reconstituted with CTLA-4-deficient bone marrow do not develop a lymphoproliferative syndrome despite lymphocyte infiltration mainly into pericardium and liver. Moreover, RAG2-deficient mice reconstituted with a mixture of normal and CTLA-4-deficient bone marrow remain healthy and do not develop any disease. Thus, the lethal disease observed in CTLA-4-deficient mice is not T cell autonomous and can be prevented by factors produced by normal T cells.

Type

Journal article

Journal

J Immunol

Publication Date

01/08/1999

Volume

163

Pages

1128 - 1131

Keywords

Abatacept, Animals, Antigens, CD, Antigens, Differentiation, Bone Marrow Cells, Bone Marrow Transplantation, CD4-Positive T-Lymphocytes, CTLA-4 Antigen, Cell Movement, Immunoconjugates, Liver, Lymphocyte Activation, Lymphoproliferative Disorders, Mice, Mice, Congenic, Mice, Inbred C57BL, Mice, Knockout, Pericardium, Radiation Chimera, T-Lymphocyte Subsets