Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level. Positive selection refers to the active process of rescuing MHC-restricted thymocytes from programmed cell death. Negative selection refers to the deletion or inactivation of potentially autoreactive thymocytes. This review focuses on interactions during thymocyte maturation that define the T cell repertoire, with an emphasis placed on current literature within this field.

Original publication




Journal article


Annu Rev Immunol

Publication Date





829 - 874


Animals, Apoptosis, Autoimmune Diseases, Calcium-Calmodulin-Dependent Protein Kinases, Cell Differentiation, Cell Survival, Humans, Isoenzymes, Major Histocompatibility Complex, Models, Biological, Peptides, Phospholipase C gamma, Receptors, Antigen, T-Cell, Receptors, Tumor Necrosis Factor, T-Lymphocytes, Transcription Factors, Type C Phospholipases